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Immune cells, such as tumor-associated macrophages (TAMs) and regulatory T cells (Tregs), promote immunosuppression and tumor growth

This was described by the original authors as "very surprising" and represented a categorically different selectivity profile from all previously characterised GHRP receptor agonists

Furthermore, there is a clear ascending trend in the number of clinical trials in cancer nanomedicine [445]

However, their dysfunction, marked by impaired oxidative phosphorylation, excessive oxygen species (ROS) production, and defective quality control, disrupts these processes and causes cellular and organ damage