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doi: 10.3389/fendo.2021.694284 26

An oral semaglutide formulation exists (branded as Rybelsus, FDA-approved for type 2 diabetes) but requires strict fasting protocols taking the pill on an empty stomach with a small sip of water, then waiting 30 minutes before eating or drinking anything else

Despite decades of lifestyle-based interventions, long-term weight loss has proven elusive for many, driving an urgent need for safe and effective medical therapies

It is also worth mentioning that this study included participants with a BMI lower than recommended for this molecule in people without diabetes, and this might influence the generalizability of the results