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( Given these limitations, there is a clear need for more rigorously designed, well-controlled, and long-term randomized placebo-controlled clinical trials to validate the real-world effects of polyphenols in the prevention and treatment of sarcopenia

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Mechanistic insights into folic acid-dependent vascular protection: dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: a novel HPLC-based fluorescent assay for DHFR activity

This decline correlates with increases in visceral fat, decreases in lean mass, reduced bone density, and skin thinning