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A total of 107 women aged 4065 years were tested among four different treatment groups that received the following treatments daily: treatment 1 contained 10 g of hydrolyzed fish collagen (HFC) ( n =27), treatment 2 contained 5 g of HFC plus 1.5 g of MSM ( n = 26), treatment 3 contained 10 g of HFC plus 1.5 g of MSM ( n = 27), and treatment 4 was the placebo control ( n = 27)

Oxidative stress markers and neurotrophins (BDNF, NGF) were quantified in the following brain regions: hippocampus, hypothalamus, striatum, cerebellum, frontal and posterior cortex

While they wont erase deep lines, consistent use can soften their appearance over time

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