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A number of sex hormones, androgens, and growth factors have been found to upregulate or to downregulate hTERT expression, so playing roles in the development and progression of cancers in androgen-responsive tissues like prostate, breast, and endometrium
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NNMTi treatment combined with lean diet substitution accelerated improved body weight fat loss, increased whole-body lean mass to body weight ratio, reduced liver epididymal white adipose tissue weights, decreased liver adiposity, improved hepatic steatosis, relative to a lean diet substitution alone
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