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Nonetheless, the tirzepatide effect of delayed gastric emptying was found to significantly reduce oral contraceptive PK by ~ 60% and, thus, the drug label advises patients using oral hormonal contraceptives to switch to or add a non-oral contraceptive method when initiating tirzepatide and after each dose escalation
Both medications may increase the risk for pancreatitis , or inflammation of the pancreas, though this may be more likely to occur in people with a history of pancreatitis or who have other risk factors
In a large Phase 3 clinical trial published in the New England Journal of Medicine, people who took the highest dose of the Wegovy pill lost an average of 16.6 percent of their body weight after 64 weeks
The Interchangeability Standard Biosimilar interchangeability is a higher approval standard that requires the applicant to demonstrate not only biosimilarity but also that patients can be switched between the reference product and the biosimilar and back again multiple times without any change in safety or efficacy
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