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Few adverse effects have been reported from healthy people taking very large doses
STEP 2 showed 1.0 mg kept about 73% of the 2.4 mg weight effect in type 2 diabetes with obesity. That is the clearest lower-dose weight evidence semaglutide has, though it is not the same as saying 1.0 mg equals 2.4 mg for everyone
Shaking can denature the peptide and reduce its effectiveness
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