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The practical takeaway: AOD-9604 has a clean safety profile in trials but a failed Phase 2b efficacy endpoint
Increased activity of an enzyme called glucose-6-phosphatase contributes to excessive gluconeogenesis (and glycogenolysis) in diabetics
PMC 3426815
Stability implications Research indicates that semaglutide reconstituted with bacteriostatic water maintains stability for 28 days when refrigerated at 2-8 degrees Celsius
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