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Glycine may ease GI upset and support muscle retention, while B-12 helps maintain energy as calorie intake dropsboth are common adjuncts in GLP-1 therapy
Begin with a low dose: It is often best to start with 500 mg once daily for about a week
One major concern is that chronic use of GLP-1 RAs may create a supraphysiological state of GLP-1, leading to gastrointestinal upset, pancreatitis, or excessive stimulation of pancreatic activity
When this process becomes less efficient, homocysteine levels may rise, increasing the risk of vascular damage
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