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The combination is appealing because using a GHRH analogue such as CJC-1295 with a secretagogue like Ipamorelin potentially allows lower frequency dosing, better control over GH peaks/troughs, and possibly fewer side effects from GH overshoot or non-GH hormone activation

Even in this last trial, CRP levels were significantly reduced compared to placebo (respectively 42.0% vs 12.8%, estimated treatment ratio 0.67

For anecdotal human evidence, high-profile users like Andrew Huberman have reported using BPC-157 for vertebral compression pain with positive results