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It allows continued monitoring of the benefit/risk balance of the medicinal product
IDO1 activity suppresses T-cell activity by depleting tryptophan, which is required for Th1 and CD8+ T-cell-mediated immunity, while kynurenine binds to the aryl hydrocarbon receptor (AHR), which directly activates Treg differentiation and activity, resulting in reduced anti-tumor responses (116118)
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Patel, T
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