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In STEP-1 (semaglutide), lean mass decreased by ~9.7% while fat mass fell by ~19.3%, with the proportion of lean mass increasing by ~3 percentage points (35)
In particular, the histological architecture of mCRPCcharacterized by dense stroma, low vascularity, and high between-tumor heterogeneityhas limited ADC penetration and distribution within tumor tissue 219,220,221,222
For a detailed explanation of every formula variable, see: Widmark Formula Explained
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