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133,134 Although it is widely accepted that those with severe depression require drug treatment, controlled trials and meta-analyses have found CBT results in similar response and remission rates as antidepressant medications, regardless of the severity of depression

It is referenced as a once-daily subcutaneous injection dosed in micrograms with gradual titration

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Hematocrit and reticulocyte counts should be repeated daily from the fifth to seventh days of therapy, and then frequently until the hematocrit is normal