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In a 23-week trial, subjects taking 1mg daily lost an average of 2.8kg compared to 0.8kg for placebo

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7 Compared with placebo, patients taking metformin had an increased risk of vitamin B 12 deficiency (number needed to harm = 14 per 4.3 years) and low vitamin B 12 levels (number needed to harm = 9 per 4.3 years)