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All transient transfections of plasmids into cell lines followed the standard protocol for Polyethylenimine Linear (PEI) Transfection Reagent (24765-1, Polyysciences Inc)
In normal physiological condition, most of APP processing chiefly in young is through the non-amyloidogenic pathway to produce the neuroprotective soluble APP alpha (sAPP) (Dar and Glazner 2020
On GD12.5, the dams were weighed and were divided into two groups: one received an intraperitoneal (i.p.) injection of 600 mg/kg of VPA (Sigma-Aldrich, St
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