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Endurance athletes deplete glutathione faster than the general population due to the oxidative load of heavy training, making daily replenishment directly relevant to recovery and immune resilience
In inflammatory contexts, NF-kB suppression is particularly relevant because chronic NF-kB activation drives the disruption of tight junction proteins (claudin, occludin) that characterizes increased intestinal permeability in colitis models
J Biol Chem (2018) 293(42):1616073
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