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In several preclinical studies, ASX has been shown to have an indirect antioxidant effect by activating the transcription factor nuclear factor erythroid 2-related factor 2 and increasing the expression of its antioxidant target genes, including phase II biotransformation enzymes [69,70,71,72,73,74]
The unsupervised clustering of 4453 fibroblasts was used to analyze the senescent cells in keloid and normal skin fibroblast based on senescence-associated marker genes, CDKN2A, TP53, CDKN1A (also known as p21 ) , LMNB1, H2AFX, TP53BP1, SFRP4, CCND1 and GLB1 according as previously reference 20,21
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These hypothalamic neurons release neuropeptides that acts on higher order integrating neurons that modulate appetite and the motivation to eat at any given time (Wee et al., 2019)
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