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Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process
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However, effects on advanced fibrosis remain under investigation, with phase 2 trials of semaglutide showing MASH resolution without confirmed fibrosis improvement
37 Rapamycin and other mTOR inhibitors similarly promote combined autophagy-mitophagy responses, improving mitochondrial integrity and cardiac outcomes in multiple disease models
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