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A 2025 genetic pharmacology study went further, identifying individuals with low baseline dopamine function as specifically vulnerable to GLP-1 agonist-induced depression and suicidal ideation ( That reading of the mechanism is what drove the treatment choice
Patients often blame themselves for past struggles with weight or cravings
Malaguarnera, M., Vacante, M., Giordano, M., Pennisi, G., Bella, R., Rampello, L., Malaguarnera, M., Li, Volti G., and Galvano, F
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