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The medication promotes natriuresis, the excretion of sodium through the urine, which helps to reduce fluid volume and subsequently lower blood pressure
This lipidation promotes albumin binding, extending its plasma half-life to approximately one week, which allows for once-weekly dosing
Int J Neuropsychopharmacol 2011, 14(01):123130
Mechanism mapping (Nature Communications, 2025) Identified the disordered p53 transactivation domain as the binding target, adding structural detail to the mechanism
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