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Their primary mode of action involves binding to ergosterol, a key sterol component of fungal cell membranes, leading to the formation of pores that disrupt membrane integrity and cause leakage of intracellular ions such as Na + , K + , H + , and Cl - , ultimately inhibiting fungal growth (Gray et al., 2012
Safety and pharmacokinetics of intravenous and oral fosmanogepix, a first-in-class antifungal agent, in healthy volunteers
Shiekh Ewelina Piktel, 1 Ilona Ociowska, 2 ukasz Suprewicz, 1 Joanna Depciuch, 3 Natalia Marciczyk, 4 Ewa Chabielska, 4 Przemysaw Wolak, 5 Tomasz Wollny, 6 Marianna Janion, 5 Magdalena Parlinska-Wojtan, 3 Robert Bucki 1 1 Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, Bialystok, 15-222, Poland
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