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During semaglutide therapy, hepatic stress increases as the body mobilizes stored fat and processes medication byproducts
For example, INT-777 and MN6, TGR5 selective agonists, stimulated GLP-1 secretion and improved insulin sensitivity in diet-induced obesity (DIO) mice [180, 181]
Hormonal Changes During Weight Loss Fat tissue isnt just storage, it plays a role in hormone regulation
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