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Mitochondrial genome instability promotes mtDNA release that engages cGAS-STING and elevates interferon-stimulated gene expression, strengthening antiviral defense, but prolonged activation provides a route to excessive inflammatory signaling that can contribute to immunopathology during infection (122)
Of course, drinking coffee with lots of high-calorie cream and sugar is likely to outweigh any weight-control benefits of caffeine
doi: 10.1073/pnas.97.22.11869 63 ZuccaFAVannaRCupaioliFABelleiCDe PalmaADi SilvestreDet al
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