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This slowing down can lead to increased absorption of nutrients, which is beneficial for blood sugar control, but may also result in the unwanted side effect of constipation

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In contrast, there are studies revealing that the activation of HIF1 signaling is not principally regulated by mutant IDH1, but more likely via other recognized mechanisms like hypoxia, transcriptional regulation, and major genetic and epigenetic alterations induced by gain-of-function or loss-of-function mutations 30