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Brayden, D

The sNDA was based on results from the Phase 3, double-blind, parallel-group, placebo-controlled cardiovascular outcomes trial, SOUL. The trial reported a 14% reduction in the risk of MACE compared to placebo when added to standard of care in patients with T2DM and established CVD and/or CKD

Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

For example, subserosal fibroids on the outside of the uterus may shrink after menopause, while intramural or submucosal fibroids inside the uterine wall or cavity are more likely to persist

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