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Malpractice is determined by whether the physician deviated from the standard of care and caused harm

It attracts immune cells and endothelial cells to injury sites, stimulates angiogenesis (new blood vessel formation), promotes fibroblast proliferation and migration, and modulates the balance between metalloproteinases (which break down damaged tissue) and their inhibitors (which protect newly formed tissue)

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The Endocrine Society's 2018 guideline on testosterone therapy notes that clinicians prescribing PDE5 inhibitors should "assess cardiovascular risk and current medications before initiation and at follow-up" [9]