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This strategy was based on previous structural data showing that position 5 of the FFAT core motif is located within a hydrophobic pocket in the MSP domain of VAP 41 , with previous studies indicating that introducing a negative charge in this position causes a steric hindrance which effectively disrupts FFAT motifVAP interaction 42
DOI: 10.1038/s41366-025-01859-6 Joy B, Ramsamooj A, Ibrahim S, et al
Phospholipids are the same types of fats that make up your cell membranes
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