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The lower-altitude higher-pressure rebound improvement observed in the mental status of the patients during Sunday afternoons, a 0.10 ATA increase from his hometown and a 0.23 ATA (3.4 psi) increase from the hypobaric/hypoxic stress zone of Eisenhower Tunnel (0.66 ATA), was in the range of bioactive pressure changes described by Kramer and Godfrey (4) (0.14 ATA increase in pressure), effects of altitude descent from the Rocky Mountains to the Great Plains (2, 3), recompression effects on patients with altitude sickness (24, 25), and the MacDonaldFraser review of bioactivity in the micropressure range of 1.0151.3 ATA (5)
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Whether the 28.7% figure replicates in a general obesity population (without OA) will be answered by TRIUMPH-1 and TRIUMPH-2, whose results are expected in mid-to-late 2026
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