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Given that all these patients had established ASCVD, I would deem them under-treated with standard lipid-lowering therapy because the average LDL-C was 78 (goal LDL-C in this population is at least 70 and had never had apo B
The reason for slow escalation is straightforward: gastrointestinal side effects like nausea, vomiting, and constipation are dose-dependent
This phase is often part of the body adapting to changes in weight, muscle mass, and overall support
And beyond raising blood levels of active glutathione (GSH) for a healthy ratio to oxidized glutathione (GSSG), it needs to be a one-supplement solution in order to remove the guesswork that seems inherent in NAC supplementation
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