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Some researchers have proposed that these drugs may also influence the biology of aging, but direct evidence in humans has remained limited
This, in turn, can cause alterations of mitochondria and nucleic acids, ceasing the ATP production and contributing to liver necrosis 1,25,26
Fatty acid synthesis is further facilitated by the availability of NADPH, a cofactor required for lipogenesis and available due to the commitment to the PPP instead of glycolysis (131)
Tirzepatide's dual GLP-1/GIP mechanism may offer slightly better insulin sensitivity improvement and greater weight loss
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