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The decision should remain individualized, grounded in clinical assessment rather than BMI cutoffs alone

The average participant entering Phase 2 Retatrutide trials had a BMI of 37.5, a starting weight around 231 lbs, and the majority carried at least two of the above metabolic risk factors

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Additional screening and caution considerations Other medical situations that require careful evaluation include: History of pancreatitis GLP-1 receptor agonists are generally used with caution in people with a history of treated pancreatitis