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Correlation of clinical response with homocysteine reduction during therapy with reduced B vitamins in patients with MDD who are positive for MTHFR C677T or A1298C polymorphism: a randomized, doubleblind, placebocontrolled study

At the same dose, a 74 kg participant had about 1.4 times the exposure of a 110 kg reference, while a 143 kg participant had about 0.8 times. Weight alone does not set the dose, but it helps explain why the trial mean transfers poorly to bodies outside the studied range

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