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This 4.2V limit is fundamental chemistry and safety: Electrochemical Stability: At voltages significantly above 4.2V (e.g., 4.3V+), the cathode material (LiCoO or similar) becomes highly unstable
However, most previous NMA studies have compared specific drugs (e.g., pioglitazone and rosiglitazone) or combinations of drug regimens (e.g., rosiglitazone+losartan, rosiglitazone+ metformin) rather than drug classes [38,39,42]
Any supplier who cannot provide an HPLC chromatogram for a specific batch is not worth considering
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