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During maturation, the NOTCH precursor undergoes a complex process of modifications and cleavages, like the S1 cleavage catalyzed by a furin-like protease before translocation of the mature protein to the cell membrane (Kopan and Ilagan, 2009)
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Probenecid : This medication increases the amount of uric acid that is excreted in the urine, by decreasing the amount that gets reabsorbed by the kidney
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