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Receptor-knockout mouse models are the standard tool for this dissection in the literature: single- and double-knockout backgrounds attenuate Retatrutides body-weight effect in a stepwise pattern consistent with a three-receptor mechanism, while Tirzepatides effect maps more directly onto its two targets
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Wardzala C, Murchison C, Loftis JM, Schenning KJ, Mattek N, Woltjer R, Kaye J, Quinn JF, Wilhelm CJ
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