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GLP-1 agonists may improve metabolic aspects but remain off-label for this indication
Also, although rare, in animal studies semaglutide caused thyroid c-cell tumors
When tirzepatide binds to these receptors, it enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying
The reasons vary from genetic factors affecting receptor sensitivity to metabolic conditions that override GLP-1 signaling to undiagnosed medical issues masking the medication effects
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