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Often, side effects can be managed by: reducing meal size avoiding fried/heavy food eating slowly correcting constipation lowering dose temporarily spacing dose escalation checking whether another condition is contributing Sometimes the solution is dose adjustment, not complete discontinuation
However, the emergence of modern obesity management medicines (OMMs), especially GLP-1 receptor agonists and dual incretin therapies such as semaglutide and tirzepatide, has dramatically changed the obesity treatment landscape
Creatine supplementation may support training performance and lean mass maintenance in this context
Genetically predicted lower BMI via GLP-1R activation was associated with better well-being, including better life satisfaction, lower neuroticism, fewer depressive symptoms, and greater positive affect
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