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Arrhythmia-Related Adverse Events Standardized MedDRA Query (SMQ): Arrhythmia-Related Events (Supplementary Appendix, Table S13) Participants with 1 arrhythmia-related event: Placebo: 2/70 (2.9%) 1 mg: 3/69 (4.3%) 4 mg (ID 2 mg): 0/33 (0%) 4 mg (ID 4 mg): 2/33 (6.1%) 8 mg (ID 2 mg): 0/35 (0%) 8 mg (ID 4 mg): 5/35 (14.3%) 12 mg (ID 2 mg): 7/62 (11.3%) Overall: 19 of 337 participants (5.6%) experienced 1 event
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[7] Causes of upper gastrointestinal bleeding that may result in melena include malignant tumors affecting the esophagus, stomach or small intestine, hemorrhagic blood diseases, such as thrombocytopenia and hemophilia, gastritis, stomach cancer, esophageal varices, Meckel's diverticulum and Mallory-Weiss syndrome
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