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Median HbA1c decreased by 8.7 mmol/mol with metformin and 14.2 mmol/mol with GLP-1RA therapy
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The pharmacological rationale is supported by GLP-1 receptor dose-response data and semaglutide's pharmacokinetic profile (Kapitza et al., J Clin Pharmacol, 2015), though no dedicated randomized controlled trial has validated a specific microdose protocol
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