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By numbing the skin at the injection site first with ice or topical creams, then you reduce some the bruising and soreness that come with weekly or monthly vitamin B12 injections
For example, Sang et al
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Spleens from MSK1/2 (serine/threonine kinase)-deficient mice accumulate eryptotic erythrocytes, and their erythrocytes are characterized by enhanced eryptosis following glucose depletion or hyperosmotic shock [152]
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