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Preliminary studies have proven many mechanisms such as oxidative stress, lipid metabolism disorders, and rennin angiotensin axis involving in the progression of hyperuricaemia-related diseases
Moreover, it has been demonstrated that the consumption of select sweeteners, when combined with a high-fat diet, can alter the composition of the gut microbiota in mice and rats, thereby affecting both microbiota dynamics and host metabolic interactions (Palmns et al, 2014
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