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Cytokine suppression: the numbers The specific cytokines reduced by GLP-1 receptor activation read like a hit list of autoimmune mediators: TNF-alpha drives joint destruction in rheumatoid arthritis , skin plaque formation in psoriasis, and intestinal inflammation in Crohn disease
TMAO and HF HF is defined as a group of syndromes caused by structural or functional damage that results in impaired ventricular filling or cardiac output, and which involves multi-organ and systemic neurohumoral dysfunction (89)
It refers to how GLP1 receptor agonists enhance insulin secretion, reduce glucagon, slow gastric emptying, and affect appetite and cardiovascular health
Persistent or severe fatigue warrants discussion with a GP or diabetes specialist to exclude alternative causes
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