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Placebo-Controlled Studies With DPP-4 Inhibition as Add-on to Ongoing Exogenous Insulin Therapy Sitagliptin, vildagliptin, saxagliptin, alogliptin, and linagliptin were also examined when added to on-going therapy with insulin in subjects with type 2 diabetes in 2426 week placebo-controlled studies with a total number of 3,196 subjects [Table 2

Biochem Pharmacol 1997

NPI-001 has the potential to treat a broad set of diseases and conditions associated with oxidative stress and reduced glutathione levels such as slowing or stopping disease progression in retinitis pigmentosa patients with functional cones, regardless of their disease-causing genetic mutation

By affecting the expression of NAMPT, TNF- indirectly influences the synthesis of NAD +