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It has been suggested that the first step in blocking mitochondria trafficking along the axon is carried out by the Ca 2+ -dependent release of mitochondria from microtubules involving the combined actions of the key adaptors of kinesins and dyneins, Miro/Milton, and syntaphilin (SNPH) [46, 47]

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This isn't arbitrary it's based on Khavinson's bioregulation framework and the protocols from the original St