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The main ingredient, berberine, can cause digestive side effects like diarrhoea, constipation, and an upset stomach

For RNA extraction, samples were thawed and processed with the NucleoSpin RNA II kit (MACHERY-NAGEL, Dren, Germany) according to the manufacturers protocol

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Clinical trials report mixed results: Shop Medications , Wellbutrin XL (150300 mg daily): 23% lost at least 5 pounds, 11% gained over 5 pounds Wellbutrin SR (300 mg daily): 14% lost over 5 pounds