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In adult patients on monotherapy, 30-50% of an administered dose appears in urine as a glucuronide conjugate

Both are the same drug, the same molecule, and use the same titration ladder

Indeed, a sub-anaesthetic, but not anaesthetic, dose of ketamine significantly increased the fraction of 13 C labelling in carbons of glutamate, GABA and glutamine upon infusion of either [1- 13 C]glucose or the glial specific substrate [2- 13 C]acetate [132]