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This suggestion is irrespective of the indication (type 2 diabetes mellitus or weight loss), dose, or the type of procedure/surgery
However, a high-fat diet and subsequent development of NASH can downregulate hepatic GLP-1R expression, thereby inducing therapeutic resistance to this medication in certain patients (Svegliati-Baroni et al., 2011
That fundamental research research like the kind Richard DiMarchi conducts has to come from laboratories at universities, smaller companies and startups. When the chemistry department recruited DiMarchi, he insisted his lab be in Bloomington, even though it initially required travel from his primary residence in Carmel, Indiana, because at the core I am a chemist, and the chemistry department at Indiana University Bloomington is world-class. Clemmer, who was chair of the department when DiMarchi joined, said he was able to recruit DiMarchi because of the opportunity to collaborate with the departments visionary researchers and access other leading academic researchers like German physician Matthias Tschp, a key player in the refinement of GLP-1 drugs for obesity treatment
We look forward to more robust data that may be available with longer periods of follow-up
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