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The mechanisms fall into four categories: vascular (angiogenesis and perfusion), matrix and cellular (collagen, fibroblasts, cell migration), protective (antioxidant and cytoprotective), and neuromodulatory (dopaminergic and serotonergic)
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Insulin resistance, visceral adiposity, gut permeability, and metabolic endotoxemia create a baseline inflammatory state that lowers the threshold for autoimmune flares
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