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YTHDF1 knockdown significantly increased the survival rate of KGN cells, but SLC7A5 overexpression effectively attenuated this protective effect (Fig
However, in the non-amyloidogenic pathway, APP via secretase is converted to the soluble APP alpha (sAPP ) which has a neuroprotective effect by reducing the accumulation of neurotoxic A and the formation of amyloid plaque (Pradeepkiran et al
Fold changes in gene expression were calculated according to the 2^Ct method (Bustin et al
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