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The gut-brain axis: These drugs interact with the area postrema in the brainstem (the region that controls the vomiting reflex) to reduce appetite, which can sometimes trigger nausea

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When semaglutide patients switch to tirzepatide In the graph below, you can see that patients who switched from semaglutide to tirzepatide, either because of greater side effects on semaglutide or because they felt they hit a plateau on semaglutide, they continued to lose weight on tirzepatide

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